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Scientists tested a new method of treatment for HIV

August 8 2008

Scientists tested a new method of treatment for HIV. Strategy to protect T-cells from HIV was invented by an international team of scientists. According to experts, it can be extended to humans. So far only passed tests on animals have shown efficiency ideas.

At the heart of the new method is based on RNA interference - the phenomenon of blocking specific gene (or genes) with specific RNA, triggering a chain reaction, inhibiting the synthesis of a protein.

In order to crank out such a focus with T-cells (a target for HIV), it is necessary to short interfering RNA (siRNA), the implemented medical patient came exactly as intended.

Scientists have come up with a molecule that transports siRNA at the indicated address. It designed an antibody that can dock with the protein, available only at the surface of T cells. To him the role of the trailer - "therapeutic" RNA, well, coupling device, coupled one to another, was a peptide oligo-9-agrinin.

Thousands of such "molecular trucks were created by experimenters and loaded with siRNA, targeted to three genes responsible: the first - a badge of HIV into T cells, the second and third - for the synthesis of proteins for the virus after infection.

To test the method, these complexes are introduced into mice, which were floating in the blood of human lymphocytes, but not their own, and who have been infected with HIV.

Turned out to be a special siRNA stop the destruction of the immune system of mice (and it they had a human), blocking the spread of the virus.

The developers of this method ection that this it is not yet ready for practical application of therapy, but a big step forward for her, wrote Potentially, such an unusual treatment may supersede the current method of "heavy" of antiviral drugs that give side effects because of their toxicity.

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