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Vaccines against tuberculosis and AIDS have been developed in Oxford

February 1 2007

Scientists from Oxford University have developed a new generation of vaccines that will help deal with such dangerous diseases as tuberculosis, malaria and HIV.

Work conducted by a team of researchers led by Adrian Hill. New vaccines lead to the combat readiness of the immune system, using adjuvants - substances that increase the immunogenicity of the antigen. Some vaccines used today reinforced adjuvants such as aluminum hydroxide. But new drugs are different in that they contain genes that allow the vaccines to produce their own adjuvants. These adjuvants mobilize the immune system against specific diseases, which can overcome the disease.

Malaria vaccines of new generation have already been successfully tested on mice, and over the next two years they will be tested on humans.

Vaccines developed by a team of Hill, used a harmless virus, which have been established for gene transfer and immunostimulatory protein. The virus is captured by antigen presenting cells and causes them to produce a small amount antigenovogo and adjuvant proteins.

Intracellular adjuvant proteins stimulate specific receptors, a cell believed that the seizure of the dangerous virus, and becomes more sensitive and therefore able to signal the immune system to fight the infection.

A couple of weeks ago, researchers have joined forces with the British company Cambridge Biostability and began joint work on a vaccine against malaria, tuberculosis and HIV. The company's specialists have learned to keep vaccines without refrigeration, which is necessary for poor countries with hot climates.

Particles vaccine sealed inside tiny sugar spheres, and which protects the contents from being destroyed at any temperature conditions. Sami areas are stored in the injection fluid indefinitely.

After introducing the solution into the bloodstream of sugar spheres are destroyed and release the vaccine. Reports Kompyulenta.

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